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Year : 2021  |  Volume : 5  |  Issue : 4  |  Page : 165-167

COVID-19 mRNA vaccination-induced lymphadenopathy mimics lung cancer metastasis on fluorodeoxyglucose PET/CT scan

Department of Radiology and Radiation Oncology, Edogawa Hospital, Edogawa-Ku, Tokyo, Japan

Correspondence Address:
Dr. Yukihiro Hama
Department of Radiology and Radiation Oncology, Edogawa Hospital, 2-24-18 Higashikoiwa, Edogawa-Ku, Tokyo 133-0052
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2588-9044.338635

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A 66-year-old man with stage IIA nonsmall cell lung cancer who had complete response to radiation therapy 4.5 years earlier underwent a fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan due to elevated CA19-9 levels. PET/CT scan showed a new cluster of left axillary and supraclavicular lymphadenopathy with increased FDG uptake suggesting lymph node metastasis. Later, it was found that the patient received the second dose of coronavirus disease 2019 mRNA vaccine 7 days before the PET/CT. Retrospective evaluation showed a vague linear-shaped metabolic activity in the left deltoid muscle with mild FDG uptake in the injection site. Based on the detailed history and PET/CT findings, a diagnosis of vaccination-induced lymphadenopathy was made. This diagnosis was confirmed after 6 months of follow-up.

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