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Year : 2021  |  Volume : 5  |  Issue : 1  |  Page : 2-5

Coeliac disease etiology and pathogenesis

Department of Internal Medicine, Norfolk and Norwich University Hospital, Norwich; MSc Gastroenterology, Queen Marry University of London, London, England

Correspondence Address:
Dr. Ali Khalifa A. Elmdaah
Norfolk and Norwich University Hospital, Coleny Lane, Norwich NR4 7UY
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/LJMS.LJMS_87_20

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Coeliac disease is a chronic inflammatory autoimmune enteropathy that affects around 1% of people worldwide. It is caused by ingestion of gluten products in people who are genetically predisposed. The pathogenesis involves multifactorial factors of genetic, gluten exposure, and environmental triggers. HLA-DQ2 and HLA-DQ8 are the main responsible genes that contribute to the development of coeliac disease. Both innate and adaptive immune plays role in the pathogenesis. In this article, we will review the causes and pathogenesis of coeliac disease development.

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