| CASE REPORT |
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| Year : 2020 | Volume
: 4
| Issue : 2 | Page : 90-93 |
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Clinical and histological features of primary pure large-cell neuroendocrine carcinoma of the ovary
Jihene Feki1, Syrine Sghaier1, Sana Ennouri1, Manel Mellouli2, Tahya Boudawara2, Rafik Mzali3, Afef Khanfir1
1 Department of Medical Oncology, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia
2 Department of Pathology, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia
3 Department of General Surgery, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia
Correspondence Address:
Dr. Sana Ennouri
Department of Medical Oncology, CHU Habib Bourguiba, University of Sfax, Sfax
Tunisia
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/LJMS.LJMS_1_20
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Primary pure large-cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare entity which has been reported only through few cases. It is described as an aggressive tumor with the tendency to present at advanced stages and to cause death after a short postoperative time. Until nowadays, there is no standard therapeutic protocol that helps to guide the treatment of this malignancy. In this article, we report two cases of pure LCNEC of the ovary to make physicians aware of this entity and to show its clinical and pathological features in order to put emphasis on its aggressiveness. The first case was a 38-year-old patient diagnosed in 2015. The ovarian LCNEC was classified according to the International Federation of Gynecology and Obstetrics (FIGO) staging classification as FIGO Stage IV and was treated by surgery and chemotherapy. The second case was a 67-year-old patient diagnosed in 2017. The ovarian LCNEC was classified as Stage IIIB and not resectable and was treated by paclitaxel–carboplatin chemotherapy.
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